covid vaccine side effects pfizer nerve damage

M, Baharlouie Quality Assessment of the Cohorts Using the Newcastle-Ottawa Scale (NOS) Modified for Cohort Studies, eTable 5. , Eom Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. 2022 Jul;92(1):158. doi: 10.1002/ana.26372. M, Sobherakhshankhah Facial paralysis following influenza vaccination: a disproportionality analysis using the Vaccine Adverse Event Reporting System Database. HF, Sy C. , Viechtbauer et al. The Egger test yielded a P value of .96, thus showing no publication bias. This study followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).31 The study protocol has been registered with PROSPERO (CRD42022313299). Silwal K, Kodali PB, Sharma H, Tewani GR, Nair PMK. S, JP, Altman 2022 May;52(3):511-525. doi: 10.1001/jamaoto.2023.0160. R, Pan The third section compared the odds of BP in Pfizer/BioNTech vs Oxford/AstraZeneca recipients. Gadolinium-enhanced MRI of the brain revealed enhancement in the left facial, trigeminal and oculomotor nerves, which persisted upon repeated examination. Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination. However, age and the severity of facial paralysis based on the House-Brackmann scale may predict poor outcomes.27. P, Moghadas Pearls & Oy-sters: facial nerve palsy in COVID-19 infection. LR, Essink Below are examples of potential symptoms: The authors of a 2023 review speculated on factors that may underlie a link between the COVID-19 vaccine and peripheral neuropathies. 2023 Jan 5;23(1):11. doi: 10.1186/s12886-022-02747-7. Anecdotal reports suggest that the vaccines may be associated with brain, spinal cord, peripheral nervous system, and cardiac inflammation. However, such an association is confirmed solely in animal studies.108,109 Likewise, the seasonal parenteral inactivated influenza vaccine was shown in the surveys of the VAERS database to have a potential association with BP incidence, as manifested by surveys of the VAERS database.110,111 Monovalent H1N1 influenza vaccines with immunologic adjuvants were also significantly associated with BP.112,113 Similarly, the quadrivalent meningococcal conjugate vaccine was also significantly associated with an increased incidence of BP.114 SARS-CoV-2 vaccines, however, do not contain adjuvants that mediate the immune response. Is the incidence rate of Bell palsy (BP) following SARS-CoV-2 vaccination different from the incidence rate in those who have not received SARS-CoV-2 vaccines? F, Tatsi L. C. Careers. TH, Haddix Of the 50 studies, 17 articles35-46,54-58 comparing BP incidence in SARS-CoV-2vaccinated and control groups that could be pooled were included in the meta-analysis, and the remaining 33 articles30,59-90 were included only in the qualitative synthesis (ie, the characteristics of which were extracted and formatted into eTable 2 in Supplement 1). Quality Assessment of the Randomized Controlled Trials Using the Cochrane Risk of Bias (ROB1) Tool, eFigure 3. , Martin-Villares Ishikawa M, Shimada Y, Ozono T, Matsumoto H, Ogura H, Kihara K, Mochizuki H, Okuno T, Sakakibara S, Kinoshita M, Okuzaki D. Front Immunol. et al; ENSEMBLE Study Group. et al. I, Calvit 2022 Apr 1;5(4):e228879. BK, All rights reserved. Three studies94-96 met the inclusion criteria; however, they used the same patient databases, hence overlapping considerably with the included studies from Hong Kong. ACY. Two of the most discussed serious side effects, anaphalaxis (a severe allergic reaction) and Guillain-Barr Syndrome (nerve damage due to inflammation), occur at a Bell palsy has also been reported following vaccination,25 although neither a causative relationship nor a prevalence of the condition higher than the general population has been established. According to the Centers for Disease Control and Prevention (CDC), GBS has occurred after people received the Johnson and Johnson (Janssen) vaccine but not after the Pfizer-BioNTech or Moderna vaccine. Therefore, the benefits outweigh the risks for most people, according to the review authors. et al. , Wan Reports of peripheral neuropathies do not prove that the COVID-19 vaccine is the cause. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. B, Kochan Kizilkilic 2023 American Medical Association. EB, Dellis S, Robins D, Sullivan Disclaimer. M, Zamani In line with this finding, prior studies56,57 also found that the risk of neurologic adverse events from SARS-CoV-2 infection is markedly higher than from the SARS-CoV-2 vaccines. The TGA closely monitors reports of suspected side effects (also known as adverse events) to the Covid-19 vaccines. JS, Hoe Thus, our results suggest that vaccinating against SARS-CoV-2 can significantly diminish the odds of BP compared with SARS-CoV-2 infection. Is the incidence rate of Bell palsy (BP) following SARS-CoV-2 vaccination different from the incidence rate in those who have not received SARS-CoV-2 vaccines? et al. Quality Assessment of the Case Controls Using the Newcastle-Ottawa Scale (NOS) Modified for Case-Control Studies, eTable 6. Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. New-Onset Amyotrophic Lateral Sclerosis in a Patient who Received the J&J/Janssen COVID-19 Vaccine. We found a March 2022 study that reported the cases of The key words GBS is rare. PMC R, Sikron optic neuritis, a swelling of the optic nerve. Neuropathic symptoms occur because of damage to the PNS. The biodistribution of the vaccine to other nerves is not known as the study 514559 checked for sciatic nerves only being anatomically closer to the injection site (hind limb) in mice. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. SARS-CoV-2 vaccines (mRNA and viral vector) in the analysis of RCTs demonstrated significantly increased odds of developing BP vs placebo. J Family Med Prim Care. K, Cohen-Ezra Lopez Bernal, J. et al. et al; SAFECOVAC study group. JP, Thompson No restriction on the study design, age of the participants, literature language, or any other factors was imposed. WebLocal reactions in persons aged 511 years, Pfizer-BioNTech COVID-19 vaccine and placebo a Mild: >2.0 to 5.0 cm; moderate: >5.0 to 10.0 cm; severe: >10.0 cm; Grade 4: necrosis Concurrent facial and trigeminal nerve palsies in a child following COVID-19 vaccination with the Pfizer vaccine. WT, Huang Ann Clin Lab Sci. [2] https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine- MH, Jr. N, Ben-Shlomo Rosenblum HG, Hadler SC, Moulia D, Shimabukuro TT, Su JR, Tepper NK, Ess KC, Woo EJ, Mba-Jonas A, Alimchandani M, Nair N, Klein NP, Hanson KE, Markowitz LE, Wharton M, McNally VV, Romero JR, Talbot HK, Lee GM, Daley MF, Mbaeyi SA, Oliver SE. , Tan Archives of Neurology & Psychiatry (1919-1959), Subscribe to the JAMA OtolaryngologyHead & Neck Surgery journal, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/index.html, https://www.who.int/news-room/feature-stories/detail/safety-of-covid-19-vaccines, https://www.fda.gov/media/148542/download, JAMA Surgery Guide to Statistics and Methods, Antiretroviral Drugs for HIV Treatment and Prevention in Adults - 2022 IAS-USA Recommendations, CONSERVE 2021 Guidelines for Reporting Trials Modified for the COVID-19 Pandemic, Global Burden of Skin Diseases, 1990-2017, Guidelines for Reporting Outcomes in Trial Protocols: The SPIRIT-Outcomes 2022 Extension, Mass Violence and the Complex Spectrum of Mental Illness and Mental Functioning, Organization and Performance of US Health Systems, Spirituality in Serious Illness and Health, The US Medicaid Program: Coverage, Financing, Reforms, and Implications for Health Equity, Screening for Prediabetes and Type 2 Diabetes, Statins for Primary Prevention of Cardiovascular Disease, Vitamin and Mineral Supplements for Primary Prevention of of Cardiovascular Disease and Cancer, Statement on Potentially Offensive Content, Register for email alerts with links to free full-text articles. P. et al; C4591001 Clinical Trial Group. , Tahir DR, Abrams F, Iskander The observed-to-expected ratios for GBS, CVT and seizure following Janssen vaccination were 1.5-fold higher than background rates. J, Zhang Funnel Plot for Observational Studies on mRNA Vaccines: Vaccinated vs Unvaccinated, eFigure 6. Events of BP in a 21-day interval after the vaccination were compared between 22760698 first-dose Pfizer/BioNTech recipients and 22978880 first-dose Oxford/AstraZeneca recipients54,56,57 (Figure 3). To address this issue, we conducted a systematic review and meta-analysis of studies reporting BP following SARS-CoV-2 vaccination to examine whether SARS-CoV-2 vaccination is associated with a higher incidence of BP compared with unvaccinated or placebo-vaccinated individuals. Despite this, rates of neurological complications following acute SARS-CoV-2 infection are up to 617-fold higher than after COVID vaccination. A, Nanishi Left Bells palsy following the first dose of mRNA-1273 SARS-CoV-2 vaccine: a case report. Quantifying heterogeneity in a meta-analysis. K. S, Jawanda X. et al. Kumari S, Anand R, Sambyal B, Singh Y, Rangappa P, Jha SK. SARS-CoV-2 infection posed a significantly greater risk for BP than SARS-CoV-2 vaccination. RV, Brando Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine through 6 months. [11] https://onlinelibrary.wiley.com/doi/10.1111/ncn3.12537, Competing interests: S, Rcker MT, Lee [7] https://www.medpagetoday.com/infectiousdisease/covid19vaccine/93537 FTT, Huang Importance A, Dubinsky-Pertzov Accessed July 2, 2022. Ann Neurol. People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. Coronavirus (COVID-19) update: July 13, 2021. For the mRNA vaccine subgroup, there were significantly increased odds of BP in the vaccinated group compared with the placebo group (OR, 3.57; 95% CI, 1.09-11.67; I2=0%; Cochran Q P value=0.46). Would you like email updates of new search results? Adverse events following mRNA SARS-CoV-2 vaccination among U.S. nursing home residents. This stems from rare reports of people experiencing neuropathy symptoms after receiving one of the vaccines. The Cochrane Collaborations tool for assessing risk of bias in randomised trials. Bell palsy (BP) has been reported as an adverse event following the SARS-CoV-2 vaccination, but neither a causative relationship nor a higher prevalence than in the general population has been established. [9] https://assets.publishing.service.gov.uk/government/uploads/system/uploa et al. M, DArrigo Instead, the virus mRNA in the vaccines might interact with the immune cellular membranes and elicit an innate immune response,107 which in turn may trigger BP, similar to the cases reported with interferon treatment.115,116. , Pothiawala Serious adverse reaction associated with the COVID-19 vaccines of BNT162b2, Ad26.COV2.S, and mRNA-1273: Gaining insight through the VAERS. Addressing the publication bias, the funnel plots are provided in eFigure 3 in Supplement 1. Minor to moderate side effects of Pfizer-BioNTech COVID-19 vaccine among Saudi residents: a retrospective cross-sectional study. , Higgins N, MS, Kim https://assets.publishing.service.gov.uk/government/uploads/system/uploa https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-ho https://doi.org/10.1101/2021.06.29.450356, https://www.medpagetoday.com/infectiousdisease/covid19vaccine/93537, https://casereports.bmj.com/content/bmjcr/14/4/e242956.full.pdf, https://onlinelibrary.wiley.com/doi/10.1111/ncn3.12537, Womens, childrens & adolescents health, Autoimmune damage to the nerves following Covid vaccines: EMA issued warning to patients and healthcare professionals.