You may also report side effects at https://www.fda.gov/medwatch. The impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should either be eliminated or given in reduced dosage in the presence of promethazine HCl (see Do not let anyone else take your medication. For sedation and relief of apprehension and to produce light sleep from which the patient can be easily aroused, Preoperative, postoperative, and obstetric (during labor) sedation, Oral and Rectal: 25 mg orally, or rectally once, then 12.5 to 25 mg every 4 to 6 hours as needed, Parenteral: 12.5 to 25 mg IM or IV every 4 hours as needed, Initial day: 25 mg orally or rectally 30 to 60 minutes before traveling, then 8 to 12 hours as needed, Succeeding days of travel: 25 mg orally or rectally upon rising, with the dose repeated before the evening meal. Promethazine HCl Rectal Suppositories are not recommended for children under 2 years of age. Call your doctor right away if you have slow, shallow, or trouble On longer trips, promethazine is usually taken in the morning and before the evening meal on each day of travel. How to classify reactions as zero, first, and second order reactions and their corresponding reactions rates. Check with your pharmacist. Hold it in place for a few moments. Adjunctive therapy to epinephrine and other standard measures for anaphylactic reactions, after acute manifestations have been controlled, Parenteral: 6.25 to 12.5 mg IM or IV every 4 hours a day, Oral and Rectal: 12.5 to 25 mg orally or rectally 2 times a day. MeSH 800-349-8919 %PDF-1.5 Mild, uncomplicated CONTRAINDICATIONS Promethazine HCl Suppositories are contraindicated for use in pediatric patients less than two years of age. Promethazine is a phenothiazine derivative, which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Promethazine HCl Rectal Suppositories, USP are available in boxes of 12 and 1000 as follows: 12.5 mg, white, bullet-shaped suppository wrapped in silver foil. There may be drug take-back programs in your area. Respiratory rate, especially in pediatric patients. WebPROMETHAZINE (proe METH a zeen) prevents and treats the symptoms of an allergic reaction. Phenergan, Promethegan, Antinaus 50, Phenadoz. Central Nervous System you should know that this medication may make you drowsy. (see It is used to treat sleep problems. For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated. This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. South Plainfield, NJ 07080 Par promethazine with codeine vs Hi-Tech promethazine with codeine? You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. WebAdults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation. , 4500 East-West Highway, Suite 900, Bethesda, Maryland. 1 receptor blocking agent. Promethazine HCl Rectal Suppositories are contraindicated for children under 2 years of age (see HHS Vulnerability Disclosure, Help 2SHCl and its molecular weight is 320.88. For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary. Please enable it to take advantage of the complete set of features! AHFS Usual adult dosage is 50 mg promethazine HCl with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid. Promethazine is also used to prevent and treat motion sickness. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. This possibility should be considered with Promethazine HCl Suppositories. Allergy The average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Before your child takes this medicine (promethazine suppositories), tell the doctor if your child is taking any drugs that can cause breathing problems. This includes your doctors, nurses, pharmacists, and dentists. You could have more side effects. 4 0 obj In the in vitro release test using a dialysis cell method, much lower amounts of indomethacin were released from the suppositories stored at a high temperature than from those stored at a low temperature. Generic name: Promethazine Suppositories [proe-METH-a-zeen] The information is not a substitute for medical care. Minor transfusion and/or amelioration of allergic reactions may be controlled with 25 mg doses. Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Minor transfusion and/or amelioration of allergic reactions may be controlled with 12.5 mg doses. If you have any questions about this medicine (promethazine suppositories), please talk Get Label RSS Feed, Methods: During a 12-month period ending in June 2021, the prescribing information and published An official website of the United States government. :u Qt/OYFTU^Jir+*;M&+X!u N1FTVpWcHxTYYM~g;|W=7 _WCB>>n>tn@Zt|f.l1Ax{x`K-n;sPVF5e.7_+Vn7b71/=Arsdnp %6y'-KhYsoK6}^tW3VJWw^TYI.JJ Do not try to test for pregnancy at home. Many times this medicine (promethazine suppositories) is taken on an as needed basis. N,N -trimethyl-, monohydrochloride, ()- with the following structural formula: Promethazine is a phenothiazine derivative, which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Remove the wrapper. Allergic conjunctivitis due to inhalant allergens and foods. This possibility should be considered with Promethazine HCl Suppositories. H-Phenothiazine, 10-ethanamine, Is NDC 0713-0526 included in the NDC Directory? Careers. Use this medicine (promethazine suppositories) as ordered by your doctor. Household teaspoons may not be an accurate measuring device. The average adult dose is 25 mg taken twice daily. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. ). Medically reviewed by Drugs.com. 3 0 obj Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Promethazine HCl 50mg. Please enable it to take advantage of the complete set of features! This medicine may cause the results of some pregnancy tests to be wrong. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 1992 Aug;46(4):223-31. doi: 10.18926/AMO/32623. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Perennial and seasonal allergic rhinitis. 25 mg, white, bullet-shaped suppository wrapped in silver foil. A paradoxical-type reaction has been reported in children receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares. (see A stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. Promethazine HCl Rectal Suppositories USP, are available as follows: Promethazine HCl Suppositories USP, 12.5 mg carton of 12 suppositories Promethazine HCl Suppositories USP, 25 mg carton of 12 suppositories Store refrigerated between 2-8C (36-46F). Dispense in well-closed container. 1989 Nov;37(11):3145-7. doi: 10.1248/cpb.37.3145. CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. Nakajima T, Takashima Y, Furuya A, Ozawa Y, Kawashima Y. Chem Pharm Bull (Tokyo). Off-label information indicates unopened bottle stable when maintained at continuous room Established labor: 25 to 75 mg IM or IV, repeated up to 2 times in 4-hour intervals. However, many people have no side effects or only have minor side effects. Promethazine HCl Suppositories are useful for: Perennial and seasonal allergic rhinitis. However, you should not flush this medication down the toilet. http://www.fda.gov/Safety/MedWatch Store promethazine suppositories in the refrigerator. Post-marketing cases of respiratory depression, including fatalities, have been reported with use of this drug in pediatric patients less than 2 years of age. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. The first-order rate constant increased with increasing pH. Promethazine HCl Suppositories, USPare useful for: If your child is throwing up for an unknown reason. Store promethazine rectal suppositories in a refrigerator between 36 - 46F. WebA stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. Antiemetic therapy in postoperative patients. See the FDA's Safe Disposal of Medicines website ( Avoid driving and doing other tasks or actions that call for you to be. Once warmed, remove from wrapper and insert high into the posterior vaginal fornix. Dermatologic Dermatitis, photosensitivity, urticaria. talk to your doctor about the risks and benefits of taking promethazine if you are 65 years of age or older. Promethazine is also used to relax and sedate patients before and after surgery, during labor, and at other times. Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 PROMETHEGAN- promethazine hydrochloride suppositoryCosette Pharmaceuticals, Inc. Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, colloidal silicon dioxide, white wax, hard fat, and glyceryl monostearate. Duplication for commercial use must be authorized by ASHP. WARNINGS Use in Pediatric Patients). Promethazine HCl Suppositories may lead to potentially fatal respiratory depression. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Study on absorption of indomethacin from sustained-release suppositories containing hydrogenated soybean lecithin in rabbits. Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. Vasomotor rhinitis. Prophylactic doses may be used to prevent nausea and vomiting during surgery and the postoperative period. 1978 Aug;67(8):1133-8. doi: 10.1002/jps.2600670828. Events, (What Preoperative, postoperative, or obstetric sedation. Phenergan, Promethegan, Antinaus 50, Phenadoz. Promethazine should not routinely be used to treat vomiting in children; it should only be used in specific cases when a doctor decides that it is needed. 2 years and older: Store promethazine tablets and liquid at room temperature and away from excess heat and moisture (not in the bathroom). Read all information given to you. The in vitro and in vivo results show that the release of indomethacin from fatty-base suppositories stored at a high temperature is less than the release from those stored at a low temperature. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. ) or by phone (1-800-332-1088). National Library of Medicine Subsequent doses on succeeding days of travel should be given on rising and again before the evening meal. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Promethazine HCl Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Caution should be exercised when administering parenteral formulations in pediatric patients 2 years of age and older; it is recommended that the lowest effective dose of oral formulations be used in and concomitant administration of other drugs with respiratory depressant effects be avoided in this patient population. Older adults should not usually take promethazine because it is not as safe as other medications that can be used to treat the same conditions. Antiemetic therapy in postoperative patients. Limited experience with dialysis indicates that it is not helpful. Instead, the best way to dispose of your medication is through a medicine take-back program. Bethesda, MD 20894, Web Policies Keep containers out of reach of children and pets. Disclaimer. Do not handle too much. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. An increase in blood glucose has been reported in patients receiving promethazine HCl. 8600 Rockville Pike tablet. Allergic conjunctivitis due to inhalant allergens and foods. Administration of 12.5 to 25 mg promethazine HCl by rectal suppository at bedtime will provide sedation in children. WebTo insert a promethazine suppository, follow these steps: If the suppository feels soft, hold it under cold, running water for 1 minute. Ask your pharmacist any questions you have about refilling your prescription. IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HCL BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED. You will need to talk about the benefits and risks official website and that any information you provide is encrypted It is soluble in water and freely soluble in alcohol. Webstore at a room temperature not to exceed 77F (25C) for up to 6 weeks. Events, PMC Store promethazine tablets, oral solution, and solution for injection at room temperature between 68 - 77F and protect from light. Keep from freezing. Drug classes: Antihistamines, Phenothiazine antiemetics. Promethazine is an H Treatment of overdosage is essentially symptomatic and supportive. It is used to help motion sickness . Patients should Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. The .gov means its official. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. Bethesda MD 20814 0713-0526-12, <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S>> Promethazine HCl 12.5mg. Use. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HCl SUPPOSITORIES HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. You may report side effects to the FDA at 1-800-332-1088. WebIndomethacin suppositories are contraindicated in patients with a history of proctitis or recent rectal bleeding. Labels, All Index Oral and rectal formulations may be used for nighttime, presurgical, or obstetrical sedation. Unauthorized use of these marks is strictly prohibited. 1990 Apr;38(4):1027-31. doi: 10.1248/cpb.38.1027. WebStore the tablets and syrup at room temperature. Take the missed dose as soon as you remember it. 17 H If you will be giving promethazine to a child, also tell the child's doctor if the child has any of the following symptoms before he or she receives the medication: vomiting, listlessness, drowsiness, confusion, aggression, seizures, yellowing of the skin or eyes, weakness, or flu-like symptoms. Promethazine can cause side effects. Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken with caution. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. Do not drive a car or operate machinery until you know how this medication affects you. Active and prophylactic treatment of motion sickness, Oral and Rectal: 25 mg orally every 4 to 6 hours as needed. Respiratory Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). Monoamine Oxidase Inhibitors (MAOI) endobj Parenteral: Treatment: 12.5 to 25 mg IM, IV, orally, or rectally every 4 hours as needed Sedating drugs may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of promethazine HCl suppositories and observed closely. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. <> (See R)EU4u:/uug83YR/^dL P?062v*6>As5>) ,]'bHK80Ume4xWTJy$yI p7[I?ruO[P8kW,]6-tg4IE&()LV l=-V4{d]|O Pre- or postoperative use: 25 to 50 mg IM or IV once Available for Android and iOS devices. You must check 8-PROMCPLNC1 Iss. It is used to ease pain . Follow all instructions closely. Do not freeze. PRECAUTIONS- Information for Patients and Drug Interactions, Cosette Pharmaceuticals, Inc. product information by RSS, Additional medications in the Prescription Medications section by. CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. sharing sensitive information, make sure youre on a federal Dermographism. The administration of promethazine hydrochloride in 25-mg doses will control minor transfusion reactions of an allergic nature. Hargoli S, Farid J, Azarmi SH, Ghanbarzadeh S, Zakeri-Milani P. Indian J Pharm Sci. Low white blood cell counts have happened with this medicine (promethazine suppositories). The site is secure. PROMETHAZINE HCL SUPPOSITORIES SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION. Mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Updated If you are allergic to this medicine (promethazine suppositories); any part of this medicine (promethazine suppositories); or any other drugs, foods, or substances. Insert the suppository Oxidative degradation of pharmaceutically important phenothiazines III: Kinetics and mechanism of promethazine oxidation. The melting point of suppositories stored at a high temperature was higher by approximately 2 degrees C than those stored at a low temperature. Do not give this medicine (promethazine suppositories) to a child who is throwing up for an unknown reason. sharing sensitive information, make sure youre on a federal Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Stimulation may be evident, especially in children and geriatric patients. Pediatric patients should be supervised to avoid potential harm in bike riding or other hazardous activities. this version. Avoid sun, sunlamps, and tanning beds. Promethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma. All Rights Reserved. Hematologic Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. (See also Nonteratogenic Effects.). Shakiness, trouble moving around, or stiffness. Promethazine HCl Suppositories are contraindicated for use in pediatric patients less than two years of age. A very bad and sometimes deadly health problem called. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Promethazine HCl Suppositories, USP are for rectal administration only. 20N Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Neuroleptic malignant syndrome (potentially fatal) has also been reported (See Pregnancy Tests Dermographism. Copyright, 2023. WebPromethazine Hydrochloride Sensitization Not applicable. Convulsions may rarely occur. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Comments: Oral or Rectal: 25 to 50 mg orally or rectally once WARNINGSCNS Depression and Avoid analeptics, which may cause convulsions. and transmitted securely. Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. This site needs JavaScript to work properly. xlI=ZMju! @ jzkZ$q{)w/_?FUV2Eg5nnf?eo w#T[)rUmp2ly!`w13?G]_LhFPpCsQH7ir_&C'57:/ Promethazine HCl Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. WARNINGSBlack Box Warning and There are many Be ready to tell or show what was Do not take 2 doses at the same time or extra doses. It may be given to you for other reasons. In the event that vasopressors are considered for the management of severe hypotension that does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered. H -Phenothiazine, 10-ethanamine, In case of overdose, call the poison control helpline at 1-800-222-1222. breathing. WARNINGS Use in Pediatric Patients). Vaginal Suppositories Allow suppository to reach room temperature just prior to administration. Store them away from light, heat, and moisture. There are many drugs that IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HCL BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED. suppository. tell your doctor if you have or have ever had an enlarged prostate (a male reproductive gland); glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision); seizures; ulcers; blockage in the passage between the stomach and intestine; blockage in the bladder; asthma or other lung disease; sleep apnea; cancer;any condition that affects the production of blood cells in your bone marrow; or heart or liver disease. ) for more information if you do not have access to a take-back program. Control) Pramlintide injection (Symlin) Promethazine suppositories (Promethegan) Proparacaine ophthalmic. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Unable to load your collection due to an error, Unable to load your delegates due to an error. taken, how much, and when it happened. If you think there has been an overdose, call your poison control center or get medical care right away. The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. advice about side effects. WebA stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. It may cause very bad and sometimes deadly breathing problems. 1 0 obj Tell your Rectal suppositories Never take suppositories by mouth. Activated charcoal orally or by lavage may be given, or sodium or magnesium sulfate orally as a cathartic. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. Talk with the doctor. Promethazine may make your skin sensitive to sunlight. Parenteral or rectal formulations may be used when patients cannot tolerate oral formulations. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required. any drug without checking with your doctor. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Ask your doctor or pharmacist if you are not sure. Treatment Promethazine HCl Suppositories may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. solution. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Do not start, stop, or change the dose of Oral or Rectal: 6.25 to 12.5 mg orally or rectally before meals and at bedtime, if necessary, OR 25 mg orally or rectally once a day at bedtime Additionally, one of each type of IVPB solution will be stored under white light and one of Do not freeze the oral liquid. In 1987, Sterchele5 described the MeSH 03/2020 VC7409, Boxed Warnings, <> WebPromethazine is well absorbed from the gastrointestinal tract. Do not share your drugs with others and do not take anyone else's drugs. If you are 65 or older, use this medicine (promethazine suppositories) with care. Sedative doses may be given the night before surgery. The .gov means its official. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=5f079815-f48b-8b21-2130-7f791d967c9a, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. Promethazine is in a class of medications called phenothiazines. PRECAUTIONSDrug Interactions). Lie down on your left side and raise your right knee to your chest. Parenteral formulations of this drug may cause severe chemical irritation and tissue damage regardless of the route. Store promethazine suppositories in the refrigerator. WebPromethazine HCl Suppositories are for rectal administration only. http://goo.gl/c4Rm4p In anesthetized rats, the plasma indomethacin levels were markedly lower than those in conscious rats, and the influence of the storage temperature on the plasma indomethacin levels was clearly observed. Talk to your doctor if you think you might be pregnant while you are taking promethazine. It works by blocking the action of a certain natural substance in the body. % Administered IV as an adjunct to anesthesia or analgesia with reduced amounts of meperidine of other narcotic analgesics in special surgical situations (e.g., repeated bronchoscopy, ophthalmic surgery, poor-risk patients), Therapy adjunctive to meperidine or other analgesics for control of postoperative pain.