The team has preached all week that their offense won't change much with the backup quarterback starting, and he'll prove them right come Sunday. -- Eric Woodyard. -- Josh Weinfuss. Pickett was picked off three times while playing in the second half last week vs. the Jets, and his ability to make good decisions on the road will go a long way against a defense tied for the league lead in interceptions (seven). -- Nick Wagoner, Embracing the fun spirit of fantasy sports, ESPN senior fantasy analyst Matthew Berry and his unconventional cast of characters aim to make fantasy football players smarter and help them win their leagues. FPI prediction: CAR, 57.9% (by an average of 2.8 points), Matchup must-reads: Fournette flourishes in Christian McCaffrey-type workload Amid defensive changes, Kuechly remains the Panthers' stopper Jaguars looking to cash in on Minshew mania Khan: No plan to trade CB Jalen Ramsey, 1 p.m. His 43.1 QBR this season is also his worst through the first four games in that same time frame. Panthers QB Young all 'business now', Bold prediction: Bears rookie running back David Montgomery finally breaks through with 100 rushing yards. That'll help the Texans continue their eight-game winning streak over the Jaguars. Betting nugget: Atlanta is 4-0 ATS this season, all as an underdog. What to know for fantasy: Marquise Brown has scored at least 12.8 fantasy points in every game this season and has at least 11 targets in three straight games. The Week 5 NFL schedule for the 2022 season is stacked with great matchups, and we have you covered with what you need to know heading into the weekend. Chiefs 24, Texans 20 -- Adam Teicher, Deshaun Watson and the Texans' offense made a big statement scoring 57 points against the Titans. Betting nugget: Chicago is 4-12 ATS as an underdog since the start of last season. Thus, breaking the streak won't be easy for the Ravens. Meanwhile, the Cowboys are tied for second in the league with 15 sacks and own the best pass rush win rate in the NFL (56.3%), according to ESPN Metrics powered by NFL Next Gen Stats. Stat to know: Trevor Lawrence struggles under pressure, having the largest drop-off of any QB in QBR (-76) compared to when he's not pressured. See Week 5 rankings. Stat to know: The Chiefs have won six straight home games on Monday Night Football with the last loss coming in 2004 against the Patriots. They'll have to do it Sunday with a lot of attention on the running game, whether Mariota or Matt Cassel is under center. Eagles 27, Cardinals 17 -- Josh Weinfuss, Larry Fitzgerald long has tortured the Eagles, averaging six catches, 99 yards and more than a touchdown per game against them in seven meetings. Josh McCown has completed 75 percent of his passes against the blitz, which bodes well against the blitz-heavy Browns, who have allowed a 127 passer rating when blitzing. So it is possible things don't get better for Stafford this week. Justin Fields is 3-9 ATS as an underdog. Betting nugget: Washington has failed to cover in three straight games. Vikings 20, Bears 17 -- Courtney Cronin, The Bears are 14-2 in their past 16 home games against the Vikings dating back to the 2001 season. The Patriots have allowed a league-high five touchdowns to tight ends this season. ET | NFL Network -- Adam Teicher, To celebrate 100 years of pro football, Peyton Manning travels the country to see the people and places that made the NFL the NFL. Matchup rating: 53.8 | Spread: TEN -3 (38.5), What to watch for: Marcus Mariota has not thrown an interception this season, but the Bills are tied with the Giants and 49ers for second in the NFL with five picks each. They're now +1.5. We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr. Plus, the Jaguars gave up 256 yards rushing last week to the Jets and now face the league's best back in Le'Veon Bell. Stat to know: The Dolphins' 11-2 record since 2021 Week 9 is tied with the Chiefs for best in the NFL. With a banged-up Steelers defense that has struggled since T.J. Watt's Week 1 injury, this game has the potential for any number of Buffalo offensive superlatives. What to know for fantasy: Through four weeks, there were 44 players with at least 25 carries. But the key in this one will be the ability of the Carolina defense to make the Lions one-dimensional and force Matthew Stafford to beat them. Betting nugget: Detroit has covered six straight road games, but it is 0-10-1 outright in its past 11 road games (0-9-1 under Dan Campbell). NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round Conference Championship Super Bowl hidden McClure's pick: Texans 24, Falcons 21 Read more. Theres not a whole lot of tape out there on Trubisky, which is a disadvantage for Minnesota in game planning. -- Vaughn McClure. The answer is to be determined. The last thing the Vikings need is for Diggs' situation to blow up into a full-blown distraction. Betting nugget: Since the start of last season, Dallas is 9-1 ATS on the road and 13-2 ATS in conference games. But Minnesotas defense is tough. Get the latest NFL Week 5 picks from CBS Sports. Read more. Betting nugget: Since the start of the 2016 season, Arizona is 3-13 ATS in 1 p.m. Christian McCaffrey, the eighth pick, leads the NFL in rushing with 411 yards, and Jacksonville's Leonard Fournette, the fourth pick, isn't far behind with 404. And the Washington passing attack? The Cowboys will want to prove last week was more of a fluke than a trend. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. (1:06). The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. He had just 14 receptions for 174 yards and zero TDs in 11 games last season. I tweaked my predictions from Sunday to reflect . Another big day could be in store for Bosa here, and don't be surprised if he brings back the "flag plant" celebration he used against Mayfield in that previous meeting. See Week 5 rankings. The answer is to be determined, Cruz expects Minshew will lead Jags over Allen's Panthers (1:17), Week 5 NFL game picks, schedule guide, fantasy football tips and more, Which NFL teams still have roster holes? He will etch his name in the record books, joining Jim Brown in 1958 as the second player in league history to score multiple touchdowns in four of the team's first five games. And the Dolphins' struggling offense presents three receivers who could give them fits once again. Read more. -- Sarah Barshop, Bold prediction: CeeDee Lamb will finish with more catches than Cooper Kupp. Colts 23, 49ers 20 -- Nick Wagoner, The last thing the Colts can do is overlook the 49ers. What's more, it's Mayfield at quarterback for the Panthers this time, the same signal-caller Bosa made a point of terrorizing in 2019 with two sacks, a forced fumble and a fumble recovery. And the Chargers have allowed 5.4 yards per rush, the second worst in the NFL. FPI prediction: CAR, 56.2% (by an average of 1.8 points), Matchup must-reads: Jimmie Ward year away from being among rarefied 49ers company Mayfield struggles, but Panthers don't have another option Nick Bosa says 49ers' defense has personnel to be 'best in the league' Mayfield takes blame for offense's struggles amid 1-3 start Darnold's return from IR not close, coach Matt Rhule says, 4:25 p.m. See Week 5 rankings. Markquese Bell capitalizing on Cowboys opportunity, The 61-0 streak is over: Why the Ravens are no longer the NFL's best closers, Raiders, Josh McDaniels savor first win vs. division rival, former employer Broncos, Mahomes' 'Houdini' play leads Chiefs' bounce-back, Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs, Patrick Mahomes says Andy Reid 'stole the show' in TV ad, Ranking early-season NFL award front-runners: Barnwell picks MVP, OPOY, DPOY, top rookies, 'Believe in yourself': Inside Kelly Kleine's historic rise to executive director of Broncos' football ops, Are the Broncos concerned about Russell Wilson? Russell Wilson's QBR in five road games against the Rams is 48.6 compared with 71.5 in his 37 other road games. This has the makings of another close loss. See Week 5 rankings. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. Herm Edwards and Tedy Bruschi discuss the outcome of what could be a high-scoring game in Dallas. UPDATE: I made seven changes to my final mock draft -- starting with the No. He is tied with Russell Wilson for the most in the NFL in that span. These two teams played last year in similar circumstances, with the Titans leaving with the victory due to Mariota's four touchdowns and a stout running game. This one could be decided by which quarterback is upright at the end of the afternoon. Bengals 14, Bills 10 -- Katherine Terrell, Coach Todd Bowles says "2-2 is nothing to brag about." Walder's pick: Eagles 23, Cardinals 20 The Steelers' 2022 quarterback journey, and what happens next, What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters, while the Lions rank first in the NFL in average yards per rush (5.9) and sixth in total rushing yards per game (164). Washington opened the. On the other side of the ball, Tom Brady said his shoulder is fine, but former Falcon Julio Jones' status is up in the air after missing the second half last week because of a knee injury. -- Turron Davenport, Bold prediction: The Bills, who possess the NFL's fourth-best rushing attack in terms of yards per game, will run for at least 150 yards against a Titans defense that has given up a combined 146 rushing yards over its past two games. How have point spreads moved for Week 5 as Sunday approaches? This is the second-longest current home losing streak in the NFL behind the Cardinals, who have dropped seven in a row at home. -- Todd Archer, Bold prediction: The first team to 30 rushing attempts will win. They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). IND-KC | CLE-SF, 1 p.m. Chicago knows how dangerous Minnesota's run game can be, so they'll stack the box to try to take away Dalvin Cook and make Cousins beat them with his arm. -- Courtney Cronin. See Week 5 rankings. Matchup rating: 77.2 | Spread: DAL -3.5 (46.5), What to watch for: Can the Packers' defense replicate what New Orleans did a week ago in holding Ezekiel Elliott to 35 yards on 18 carries? Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . Betting nugget: Both times Rodgers faced the Cowboys in Dallas, Green Bay won the game outright as an underdog (2016 divisional round and 2017 Week 5). See Week 5 rankings. LAC-CLE | SEA-NO | TEN-WSH Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, What to watch for: Justin Herbert finished with 398 passing yards in the Chargers' win over the Browns last season, the most Cleveland surrendered in any game in 2021. That includes losses to the Titans and Colts in the past two weeks. Commanders WR Curtis Samuel has 26 receptions this season, tied with Travis Kelce and Davante Adams for eighth most in the NFL. Let's get into the full Week 5 slate, including another London showdown (Giants-Packers), Kenny Pickett's first start, Jalen Hurts vs. Kyler Murray and an AFC North meeting between the Bengals and Ravens. The Week 5 NFL slate is stacked with great matchups. -- Mike Reiss. Jump to a matchup: What to know for fantasy: With two games of seven-plus targets already this season, plus a TD reception in Week 4, Bengals tight end Hayden Hurst has potential. Jets' high-priced, underperforming offensive line receives wake-up call Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', 1 p.m. Davenport's pick: Titans 17, Bills 14 MIN-NYG | NYJ-PHI | JAX-CAR Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. What to know for fantasy: Austin Ekeler scored more fantasy points last week in Houston (34.9) than he did in the two weeks prior combined (31.7). -- Ben Baby. (Game times are Sunday unless otherwise noted. Experts weigh in with analysis and provide premium picks for upcoming NFL games. Tyrod Taylor has excelled in passing to Charles Clay and LeSean McCoy this season, but the Bengals boast the NFL's lowest yards per catch (6.49) by opposing tight ends and running backs. Lamb has been targeted 42 times with 23 catches for 288 yards. Philadelphia is allowing a league-low 4.75 yards per pass, and the Cardinals are ranked 30th in passing yards per play (5.37). Steelers' first draft by Khan 'aggressive' Chargers-Saints point spread: Saints -8.0 (over/under 50.0) FPI prediction: PHI, 75.9% (by an average of 9.7 points), Matchup must-reads: Jalen Ramsey to the Eagles: What are the realistic odds? NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . That's tied for the most outright wins without a loss in any matchup in NFL history, according to Elias Sports Bureau research. But he'll face a Redskins defense that, on third down, allows QBs to complete 87.2% of their throws and post a 140.5 passer rating. Pick NFL winners straight up or against the spread and compete to win more than $14,400 in prizes! Read more. -- Jenna Laine, Bold prediction: The Falcons, with no Cordarrelle Patterson and against a good run defense, will manage to once again top 150 rushing yards with Tyler Allgeier leading the way. Betting nugget: Both Allen and Gardner Minshew II are 3-0 ATS in their careers as starters. The Chargers are 2-6 when the Broncos have intercepted Rivers at least twice and 5-11 when Denver has intercepted him at least once. What to know for fantasy: Darnell Mooney hauled in 17 of 25 targets for 183 yards when playing the Vikings last season. Through four games, they have collected an NFL-low 390 passing yards -- the fourth fewest by any team at this point in a season since 2000. I've been talking with execs, scouts, coaches and other evaluators around the league to get the latest surrounding how each team might use their 2023 NFL draft . While they are struggling in the passing game, the Bears are third in the NFL in rushing yards (709). What to know for fantasy: Receiver Sammy Watkins scored 46.8 points in Week 1, but that is 18.1 more fantasy points than he has scored in the three weeks since. Bengals quarterback Joe Burrow has excelled in his past eight road games, going 6-2 with 18 touchdowns and four interceptions. Jalen Ramsey to the Eagles: What are the realistic odds? FPI prediction: LAC, 57.5% (by an average of 2.3 points), Matchup must-reads: Chargers hope to get on track Browns' schedule gets difficult from now on Garrett back at Browns practice for first time since car crash, What to watch for: It looks like another week without Winston and wide receiver Michael Thomas, which would mean Andy Dalton will likely take over again at quarterback. This is a matchup of the worst passing offense in the NFL (Jets, 131 yards per game) vs. the worst passing defense (324 yards per game). Betting nugget: The Broncos are 1-7 ATS in their past eight games. The Jags likely won't have cornerback Jalen Ramsey, and the domino effect of his absence will be a major issue when McCaffrey lines up on the outside. Since 2011, games with totals of 55 or higher are 33-22-1 to the over. -- Mike DiRocco. Moody's pick: 49ers 27, Panthers 10 That should change against a Tampa Bay team that is averaging 31 points per game and allowing 29. What to know for fantasy: Zach Ertz finished last season as TE2 despite not scoring his first touchdown until Week 5.