Need help? This calculator is for people aged 18 years or older. Inulin is freely filtered by the kidney and does not undergo metabolism, tubular secretion, or absorption, making it an ideal candidate for measuring GFR.2 This measurement method requires continuous intravenous infusion, a number of blood and urine collections, and proper timing of blood samples, making it impractical for routine clinical use.3 As such, many formulas have been developed to estimate GFR, many of which are based on creatinine clearance, or estimates of creatinine clearance based on serum creatinine levels. With the use of internationally standardized creatinine measurements, the equation significantly overestimates the GFR (10-40%). "Measured GFR as 'Gold Standard' All that Glitters Is Not Gold?" Knowing your eGFR is also important to managing your health at every stage of kidney disease. Healthy kidneys filter creatinine out of the blood. Adults: Use either the Modification of Diet in Renal Disease (MDRD) Study equation or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The typical range for serum creatinine is: The measure of serum creatinine may also be used to estimate how quickly the kidneys filter blood (glomerular filtration rate). Learn how to look after your kidney health and thrivein a class that fits your life. Creatinine Clearance (Cockcroft-Gault Equation) Calculates CrCl according to the Cockcroft-Gault equation. All GFR estimating formulas on this site are designed for use with standardized creatinine and standardized cystatin C values. Your exact GFR cannot be measured directly. The creatinine clearance calculator finds the creatinine clearance (CrCl), which is an estimate of the glomerular filtration rate (GFR).A commonly used creatinine clearance formula is the Cockcroft-Gault equation.. Either of the following must be present for 3 months to be CKD: In the absence of evidence of kidney damage, neither GFR category G1 nor G2 fulfill the criteria for CKD. How is GFR Determined and Interpreted? Albumin is a protein in blood. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. official version of the modified score here. GFR is one of the most important indicators that provides information on overall kidney function. The following is theIDMS-traceable MDRD Study equation(for creatinine methods calibrated to an IDMS reference method), GFR (mL/min/1.73 m2) =175 (Scr)-1.154 (Age)-0.203 (0.742 if female) (1.212 if African American). The equation has been validated extensively in Caucasian and African American populations between the ages of 18 and 70* with impaired kidney function (eGFR < 60 mL/min/1.73 m2) and has shown good performance for patients with all common causes of kidney disease.2. Stage 1 CKD also hasan eGFR range of 90 or higher because kidney damage is minimal at this stage. A GFR score below 60 suggests kidney disease. Creatinine-based estimating equations should be used only for patients with stable creatinine concentrations. This can mean something different for everybody, since your eGFR also depends on your age, gender, muscle mass, ethnicity, and the results of your creatinine serum test. Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Physical Symptom Cluster Subgroups in Chronic Kidney Disease. The equation is given in the following table for creatinine in mg/dL (see Appendix for creatinine in mol/L). The equation does not require weight or height variables because the results are reported normalized to 1.73 m2body surface area, which is an accepted average adult surface area. GFR = [UCr x V] SCr This formula is called the creatinine clearance and tends to exceed the true GFR by 10 to 20 percent or more depending upon the proportion of urinary creatinine that is derived from tubular secretion [ 4 ]. However, shorter time periods for urine samples may be used. Patients under the age of 18: Calculate eGFR using the Schwartz equation for patients under age 18. Creatinine clearance is usually determined from a measurement of creatinine in a 24-hour urine sample and from a serum sample taken during the same time period. Estimating equations become less accurate as GFR increases. 1-888-373-1470, Need help? A non-indexed eGFR value (i.e. Calculates CrCl according to the Cockcroft-Gault equation. eGFR Calculator. Kidneys help clean blood of different waste products and toxins and transport them out of the body through urine. Creatinine. 2016-2023 Fresenius Medical Care. A creatinine test is a measure of how well your kidneys are performing their job of filtering waste from your blood. GFR = 141 min (Scr /, 1) max(Scr /, 1)-1.209 0.993Age 1.018 [if female] 1.159 [if black] Accuracy of the CKD-EPI and MDRD equations to estimate GFR for the validation data set (N=3896). eGFR is more accurate than serum creatinine alone. SCr = the serum creatinine, either expressed in mg/dL. *The equation has not been validated in patients older than 70, but an MDRD-derived eGFR may still be a useful tool for providers caring for patients older than 70. Once you enter the requested information the GFR calculator will be ready to offer the detailed information. The MDRD equation cannot be used for acute renal failure. Additionally, the equations are not recommended for use with: Application of either the MDRD Study or CKD-EPI equation to these patient groups may lead to errors in GFR estimation. 2009;53(6):9325. However, many drug dosing recommendations for patients with decreased kidney function were based on creatinine clearance calculations from the CG equation, and it remains one option for determining drug dosage and discontinuation. Use the chart below to determine which CKD stage best matches your GFR calculator results and click on the stage to learn about healthy next steps. Creatinine is a chemical compound left over from energy-producing processes in your muscles. For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics. Hsu, C., Bansal, N. 2011. But even people whove taken excellent care of their health can be at risk for CKD. Because mild and moderate kidney injury is poorly inferred from serum creatinine alone, NIDDK strongly encourages clinical laboratories to routinely estimate glomerular filtration rate (GFR) and report the value when serum creatinine is measured for patients 18 and older, when appropriate and feasible. When to Use Pearls/Pitfalls Why Use Sex Female Male Age years Weight lbs Creatinine mg/dL Normal GFR varies according to age, sex, and body size, and declines with age. All Rights Reserved. The MDRD equation performs equally to the newer. Incase of adultsthere are few methods to determine GFR as they are presented below: The IDMS-traceable MDRD equation formula: GFR = 175 * (SCr)-1.154* (Age)-0.203* (0.742 only if female) * (1.212 only if black). A significant decrease in GFR indicates that the kidney is not properly functioning, resulting in lower volumes of fluids being filtered over a given time. To help preserve your current kidney function, talk to your care team about how you can protect your kidney health. Creatinine is produced in the body at a constant rate and is freely filtered and not reabsorbed although a small amount of creatinine is secreted by the tubules. Glomerular filtration rate (GFR) is the best overall index of kidney function. Glomerular filtration rate is a measurement of how well your kidneys are working to clean your blood. If youre using our GFR calculator, your eGFR is calculated using the results of your blood test, along with your age, ethnicity, and gender. Request Patient Travel Services Information, DONT WAIT TO GET TESTEDIT CAN SAVE YOUR LIFE.. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. What Does Glomerular Filtration Rate (GFR) Tell Us About the Kidneys? Enter a numeric height of at least 0.1 centimeters (cm), Estimated Glomerular Filtration Rate Calculators, U.S. Department of Health and Human Services, National Kidney Foundations eGFR calculator, Estimating Time to ESRD in Children with CKD calculator, National Institute of Diabetes and Digestive and Kidney Diseases. Creatinine Test Results. Your support helps families facing kidney disease at every step of their journey. For estimating GFR from serum creatinine in patients under age 18 (including infants, toddlers, children, and teens), the Bedside Schwartz equation should be used. Glomerular filtration rate describes the rate of flow of filtered fluids through the kidney and is used as a measure of kidney function. Furthermore, creatinine is actively secreted in small amounts in the body resulting in GFR determined through creatinine clearance typically being overestimated by 10-20%. This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases max indicates the maximum of Scr / or 1. To learn more, click, Your support helps families facing kidney, CKD-EPI Creatinine-Cystatin Equation (2021), Pediatric Chronic Kidney Disease Risk Calculator, CKD-EPI creatinine-cystatin equation (2021). eGFR calculators that provide estimates without use of a race coefficient are preferred for adults and children.1 Assessing eGFR trends to observe kidney function change over time, rather than using a single point estimate of eGFR, may provide a more meaningful indicator of prognosis. This practice will reduce rounding errors that may contribute to imprecision in the eGFR value. Your estimated glomerular filtration rate (eGFR) is the calculation that indicates your level of kidney function, based on the results of a creatinine serum test and other factorssuch as age, gender, muscle mass, and ethnicity. Use of any serum creatinine-based estimate requires that kidney function be at a steady state. To calculate your eGFR, enter all fields below. INSTRUCTIONS For use in patients with stable renal function to estimate creatinine clearance. The CKD-EPI formula is different for each of the cases presented below: - The GFR = e(1.911 + 5.249/SCr- 2.114/SCr2- 0.00686 * Age - (0.205 only if Female)). The original Cockcroft-Gault equation, derived in 1976, relied on non-standardized creatinine measurements. American Association for Clinical Chemistry. GFR may be best assessed by monitoring trends over time rather than a single point estimate. Doi:10.2215/CJN.06040611. A smoothed regression line is shown with the 95% CI for the distribution of results, using quantile regression, excluding the lowest and highest 2.5% of estimated GFR. More information regarding this recommendation may be found here. Calculate eGFR from stable serum creatinine levels at least once a year in all patients with diabetes. Choose an educator-led or self-guided format. Comparing the estimates from both calculators may provide a more informed assessment of kidney function for the patient. Development and validation of GFR-estimating equations using diabetes, transplant and weight. Caution: It is important to know the method used to measure creatinine in a blood, serum, or plasma sample, as it will affect the formula for estimating GFR in children. 2009;75(10):10718. 2005;16(2):459466. The formula for calculating GFR takes into account the serum creatinine count and other factors, such as age and sex. Comparing the estimates from both calculators may provide a more informed assessment of kidney function for the patient. The CKiD bedside equation calculator uses serum creatinine and height to estimate GFR in children ages 1 to 16. Laboratories should program their information systems to use an IDMS traceable creatinine-based equation to automatically estimate and report GFR for patients ages 18 and older, when appropriate and feasible. Both CrCl and GFR can be measured using the comparative values of creatinine in blood and urine. Calculate estimated GFR (eGFR) from serum creatinine levels to assess kidney function. The usual methods determine GFR based on blood test results or by comparing the ingredient in a blood sample with the one in a sample of urine. It is only useful in estimating glomerular filtration rate (GFR) in stable chronic kidney disease. Results from creatinine in blood or urine are measured and interpreted in many ways, including the following: Creatinine usually enters your bloodstream and is filtered from the bloodstream at a generally constant rate. min indicates the minimum of Scr / or 1, (NIDDK), part of the National Institutes of Health. Accessed Dec. 2, 2015. The glomerular filtration rate (GFR) is a lab value that looks at kidney function. A creatinine urine test can measure . For persons under 18 years of age, use the pediatric GFR calculator. However, the CKD-EPI equation was more accurate in a subgroup with eGFR between 60 and 120 mL/min/1.73 m2. All rights reserved. All estimating equations estimate GFR. 2018;71(6):783792. A unifying approach for GFR estimation: recommendations of the NKF-ASN Task Force on reassessing the inclusion of race in diagnosing kidney disease. 2021;99(4):948956. In particular, the result may indicate a complication of diabetes called diabetic nephropathy, or diabetic kidney disease. GFR-estimating equations have poorer agreement with measured GFR for ill hospitalized patients and for people with near normal kidney function than for the patients in the MDRD or CKD-EPI Study.